First, cast your line out over a body of water where you have seen evidence of active fish feeding patterns, such as jumping or splashing around on top of the water surface. Give your bait about five seconds before beginning your retrieve pattern. The loud splash can sometimes spook fish that are close by. This gives them a few seconds to settle in. Use quick jerks of the rod tip followed by small pauses; this will create a "walking" action on top of the water surface that mimics real aquatic life and entices those hungry fish into striking at your bait! You can also fish these wake baits on a steady retrieve. Wake baits are designed to create a huge wake behind the bait drawing in big strikes from great distances.
Here is a video by FishLab product designer, Mike Bennet on fishing the Bio-Shad Wake Baits.